by a CD137 x 5T4 bispecific ADAPTIR™ Molecule Requires Co-engagement of CD137 and 5T4. Gabriele Blahnik-Fagan, Robert Bader, Jeannette Bannink, 

T1 - Expression of CD137 (4-1BB) on Human Follicular Dendritic Cells. AU - Lindstedt, Malin. AU - Johansson Lindbom, Bengt. AU - Borrebaeck, Carl. PY - 2003.

Validated in IHC and tested in Human. Cited in 2 publication(s). Independently reviewed in 1 review(s). Immunogen corresponding to fusion protein. CD137, also known as 4-1BB, is a member of the TNFR super family.

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Köp boken CD137 Pathway: Immunology and Diseases (ISBN 9780387313221) hos Adlibris. Fri frakt. Pris: 205,6 €. e-bok, 2015.

Pris: 205,6 €. e-bok, 2015. Laddas ned direkt.

CD137 is a member of the tumor necrosis factor (TNF) receptor family and the human homologue of mouse 4-1BB (1). Similar to its mouse counterpart, human  

4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways.

CD137, also known as 4-1BB, is a TNFR family member that is expressed on activated T cells, NK cells and a number of other activated cells of hematopoietic  

CD137 is mainly expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer cells, but can also be found on resting monocytes and dendritic cells.

CD137 has also been evaluated as a target molecule to selectively deplete alloreactive T cells in vitro [147].
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This allowed to identify the CD137+ T-cells as the real tumor-specific activated T-cell population. In fact, these cells express various TCRs that are specific for The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 … Rat anti Human CD137 antibody, clone JG1.6A recognizes human CD137, an 83kD type I integral membrane protein, otherwise known as 4-1BB.

Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule. 4-1BB (CD137) is a costimulatory member of the tumor necrosis factor receptor superfamily that is upregulated on activated T cells, NK cells, NKT cells, and monocytes. 4-1BB is also expressed on Tregs and DCs. CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes.
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CD137 is a costimulatory member of the TNF receptor superfamily that is expressed on a variety of immune cells following activation, including T cells, dendritic cells, and natural killer cells. Signaling via CD137 can lead to cytokine induction, prevention of activation-induced cell death, and

CD137 is a kind of surface glycoprotein, which was originally discovered in the late 1980s. 6 It has been found that CD137 is expressed in a vari- ety of cells, for example, T cells, B … CD137. CD137 expressed on blood vessels in inflamed tissue correlates with markers of vascular inflammation, and the use of an anti-CD137 antibody promotes the accumulation of T cells in atherosclerotic lesions in a murine model [63]. From: Journal of Autoimmunity, 2020. Related terms: Neoplasm; T Cell; Antigen; Antibody; Immunotherapy; Ligand CD137 (TNFSFR9) was originally identified as a molecule induced on the surface of activated mouse and human CD4+ and CD8+ T cells, with its expression undetectable on non-activated T cells.

TNFRSF9 / 4-1BB / CD137 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses.

Urelumab. Anti-OX-40 kostimulatorisk. Anti-CD27 kostimulatorisk. Anti-CCR4. Inhibiton av Treg1.

Co-stimulatory molecules, such as CD137, are key regulators of inflammation, and CD137 activity regulates inflammation in experimental atherosclerosis.